Pipeline Allegro seeks to uncover groundbreaking treatments for eye care patients who have limited or no options, or who inadequately respond to existing therapies. more… Therapeutic Areas Allegro focuses on ocular diseases with unmet needs such as intermediate dry AMD, DME and dry eye disease.

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clinical trial for the treatment of dry eye disease will be presented at ASCRS. Allegro Ophthalmics announced the expansion of the company’s anti-integrin portfolio with the new topical dry eye disease drug candidate ALG-1007. ALG-1007 bolsters Allegro’s existing anti-integrin portfolio, which includes risuteganib (Luminate), currently being developed for diabetic macular edema (DME) and intermediate dry age-related “ALG-1007 represents Allegro’s first exploratory drug beyond the retina.

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proof-of-concept clinical trial of the new investigational ALG-1007 topical drop drug candidate in patients with dry eye disease (DED). ALG-1007. 05.14.19. Allegro Announces Positive Results of Ex-US Proof-of-Concept Trial With ALG-1007 for Dry Eye Disease.

Allegro Ophthalmics, LLC is a late-stage ophthalmic biopharmaceutical company focused on redefining the retina space with integrin inhibition therapy,

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We recognize the need to bring in independent external expertise that complements our company’s strengths and are thrilled to have such an outstanding group of advisors as Drs. Lindstrom, Holland and Donnenfeld help shape and accelerate our clinical program for dry eye disease.” 2020-09-21 Allegro Ophthalmics announced positive results of an ex-US proof-of-concept clinical trial of the new investigational ALG-1007 topical drop drug candidate in patients with dry eye disease (DED). The results were presented by Eric D. Donnenfeld, MD, last week at the 2019 American Society of Cataract and Refractive Surgery and American Society of Ophthalmic Administrators (ASCRS•ASOA) Annual … ALG-1007 has successfully completed an ex-U.S.
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CHICAGO, IL — October 16, 2014 — Allegro Ophthalmics, LLC, dedicated to establishing integrin peptide therapy as the next-generation pharmaceutical category for the treatment of vitreoretinal diseases, today announced that it is enrolling patients in a Phase 2 trial that will evaluate the safety and efficacy of Luminate®, previously known as ALG-1001, in patients with diabetic macular edema (DME).

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ALG-1007 (Allegro Ophthalmics, San Juan Ca pistrano, CA, USA) is a topical applica tion of risuteganib, a small peptide . integrin regulator that m odulates multiple in tegrin subunits,

“Allegro is excited to share our ex-U.S. proof-of-concept data of ALG-1007 for dry eye disease,” said Vicken Karageozian, M.D., President and CEO of Allegro Ophthalmics. “These early results suggest that ALG-1007 improves the signs and symptoms of dry eye, a disease that affects millions of people globally, with symptoms that include scratchy, stinging or burning sensations, and pain or 2019-05-14 Today, Allegro also announced that the results of its ALG-1007 ex-U.S. proof-of-concept clinical trial for the treatment of dry eye disease (DED) will be presented during the 37 th Congress of the ALG-1007 bolsters Allegro’s existing anti-integrin portfolio, which includes risuteganib (Luminate ®), currently being developed for diabetic macular edema (DME) and intermediate dry age-related macular degeneration (intermediate dry AMD).Pre-clinical and clinical findings of risuteganib convinced the company that it could develop a new anti-integrin compound to treat DED. Allegro has expanded its anti-integrin portfolio with the development of ALG-1007 for topical use in dry eye disease Its lead investigational compound , risuteganib , is being studied in dry AMD and DME ALG-1007 is a topical integrin regulator in development for potential use in patients with dry eye disease. ALG-1007 demonstrated a strong signal in an ex-U.S. proof-of-concept clinical trial in which it showed a dose-response curve and that it was generally well-tolerated. 2019-05-17 Expanding its integrin-regulating portfolio, Allegro has developed ALG-1007 for topical use in dry eye disease.

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